ss-31 peptide
SS31, also known as Elamipretide (D-Arg-Dmt-Lys-Phe-NH₂), is a cell-permeable Szeto-Schiller tetrapeptide that selectively concentrates at the inner mitochondrial membrane and binds cardiolipin. In preclinical research it has been studied for stabilizing cristae architecture, preserving electron transport chain super-complex assembly, reducing mitochondrial reactive oxygen species, and restoring ATP synthesis in models of ischemia-reperfusion, heart failure, and age-related mitochondrial dysfunction.
SS-31 (also known as elamipretide, Bendavia, or MTP-131) is a mitochondria-targeted synthetic tetrapeptide. By binding to cardiolipin in the inner mitochondrial membrane, it stabilizes the electron transport chain, reduces oxidative stress, and boosts cellular energy (ATP) production. [1, 2]
- Cellular Energy: Repairs mitochondrial membranes, addressing age-related or stress-induced drops in cellular energy.
- Antioxidant Action: Scavenges reactive oxygen species (ROS) and prevents mitochondrial apoptosis (cell death).
- Clinical Development: Developed by Stealth BioTherapeutics, it has been primarily studied in clinical trials for rare mitochondrial disorders like Barth syndrome, primary mitochondrial myopathy (PMM), and heart failure. [1, 2, 3, 4]
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